Physical Chemistry Research Laboratory
Faculty of Engineering and Natural Sciences, Altınbaş University
Natural Products R&D Center (DÜAGEM)
Faculty of Pharmacy, Altınbaş University
1. Development of novel biopolymer nano- and microcomposite materials for environmental, medicinal and pharmaceutical applications
Polysaccharides are one of the most abundant materials in our earth. Besides their abundancy, they are generally non-toxic, biodegredable and easily modifiable. For instance, in our several studies we used alginate, a negatively charged and well-known biopolyelectrolyte. In a drug delivery and protein entrapment study, we modified the alginate matrix with another natural material (montmorillonite clay) in order to obtain a potential oral protein delivery agent. The clay layers are first expanded and then exfoliated in the presence of model protein and alginate, giving high protein entrapment efficiency and good in vitro drug delivery characteristics. We used the same system in order to develop a drug delivery device for smaller drugs (e.g. vitamins). Besides drug delivery, porous structures of these materials can be used for water purification. We are able to remove inorganic anions and organic molecules by improving biopolymeric materials with organic and/or inorganic dopants.
Chitosan is another biopolyelectroylte, which is able to form crosslinked gel structures. In a recent study, we developed a cerium(III)-alginate-chitosan biopolymer composite wound dressing which shows good antibacterial properties against gram positive and negative bacteria.
2. Green synthesis of metal oxide nanoparticles (<25 nm)
Green chemistry is gaining importance due to the pollution and energy concerns. In this scope, we aim to synthesize nanosized metal oxides using non-toxic biopolymers as precursors. This technique is based on one-step synthesis of nanometal oxides with a narrow size distribution and functionalized surface.
Statistical analysis of the chemical data obtained from plant extracts and nutrients is important on the classification and cluster analysis of the samples. In order to establish a connection between botanical origin and chemical properties of the samples, different statistical methods can be applied. In our two recent papers, we applied principal component analysis to 20 different Anatolian honey samples and Turkish honeybee pollen samples. Principal component analysis was applied to analyze results in order to classify the samples from different botanical origins and regions.
4. Effect of surfactants on bio-polyelectrolyte multilayers and gels
Layer-by-layer (LbL) deposition technique is a useful tool for structural characterization of polyelectrolytes. We aimed to observe the effect of surfactants on oppositely charged
biopolyelectrolytes, alginate and chitosan using the LbL technique. Thin films with thicknesses in nanometers were prepared and the samples were characterized using X-ray
reflectometry, ellipsometry, atomic force microscopy (AFM) and ellipsometry. We found that the binding of anionic surfactant sodium dodecylsulfate to alginate chain via hydrophobic
interactions, surprisingly, increased the thickness of the polyelectrolyte multilayer films. It is even possible to tune the alginate-chitosan complexes in molecular level by adding
5. Monte Carlo simulation of chemical systems
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